Search  ![You can choose the species of interest and then to select, one at a time, official gene symbols or aliases using the search box, which autocompletes for ease of use. Otherwise, you can directly paste a list of gene symbols into the query textbox.
Up to 10 genes are allowed for clarity of visualisation.
The gene list of interest in the query textbox is retained if the researchers would change species. Examples of possible geneset are also present.](images/info.png)
1 gene found on 1: RRAGC TFEB GENE PERTURBATION
TIME SERIES (GSE98247)      GP Score  
    
| | NETWORK     ![The “NETWORK” panel reports a TFEB network diagram to graphically depict the genes that are significantly modulated in the time-series data.
The values on the edges are the GP score values.
In the network diagram, TFEB targets are shown as red circles. On each circle there is a link to the gene card website; an additional link is shown for those genes (filled cyan circles) belonging to the KEGG autophagy pathway.](images/info.png) |
TFEB Target          KEGG Autophagy    ![](images/leg2.png) |
Fold Change (log2t/t0) |
| COLOR LEGEND
■ RRAGC
|
|
BIOINFORMATIC PREDICTION OF BINDING SITES
Homo Sapiens (hg19)    
   Upstream  
   Downstream  
   PWM Score  
    
Genesymbol |
Score |
Binding Site |
Chrom |
Start |
End |
Strand |
TSS Position |
Promoter Sequence |
View |
RRAGC | 0.9741982 | GGCACGTGAC | chr1 | 39325549 | 39325558 | - | -62 | Promoter | IGV |
|
EXPERIMENTAL ChIP-seq
ChIP-seq HEK-293 (GSE98246)      Upstream  
   Downstream  
    
Genesymbol |
Chrom |
Start |
End |
TSS Position |
View |
RRAGC | chr1 | 39325474 | 39326057 | 0 | IGV |
|
ChIP-seq HeLa (Palmieri et al., HMG 2011 - ChIP-seq Palmieri HMG )
Genesymbol |
Chrom |
Start |
End |
TSS Position |
View |
RRAGC | chr1 | 39325313 | 39325853 | 0 | IGV |
|
Copyright © 2020 Tigem. Designed by Diego Carrella
in collaboration with Rossella De Cegli
Data produced by Ballabio’s and di Bernardo’s lab
Please cite: Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella,
Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio & Diego di Bernardo (2022) TFEBexplorer:
An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB,
Autophagy Reports, 1:1, 295-305, DOI: 10.1080/27694127.2022.2097822
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