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Species	Gene Symbols / Aliases
Homo SapiensMus MusculusRattus Norvegicus
Up to 10 RRAGC
Examples:     mTOR regulators     Autophagy-Lysosomal

TFEB GENE PERTURBATION

TIME SERIES (GSE98247)      GP Score   >3ALL			NETWORK	TFEB Target          KEGG Autophagy
Fold Change (log2t/t0)		COLOR LEGEND ■ RRAGC

GENE EXPRESSION PROFILE      FDR   <5%ALL

Genesymbol Experiment FDR Signed Ratio RRAGC TFEB HeLa - OE (GSE16267) 0.001584169 1.676950057 RRAGC TFEB-GFP HeLa - OE (GSE73055) 1.44e-06 -1.362631813 RRAGC TFEB-3xFLAG HeLa - OE (GSE73054) 1.05e-05 -1.396936467

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BIOINFORMATIC PREDICTION OF BINDING SITES

Homo Sapiens (hg19)        Upstream   2000 1500 1000 500 200 100    Downstream   500 400 300 200 100 0    PWM Score   0.85 0.90 0.95 1 Genesymbol Score Binding Site Chrom Start End Strand TSS Position Promoter Sequence View RRAGC 0.9741982 GGCACGTGAC chr1 39325549 39325558 - -62 Promoter IGV

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EXPERIMENTAL ChIP-seq

ChIP-seq HEK-293 (GSE98246)      Upstream   1000 5000 2500 1000 300    Downstream   1000 5000 2500 1000 300 Genesymbol Chrom Start End TSS Position View RRAGC chr1 39325474 39326057 0 IGV

ChIP-seq HeLa (Palmieri et al., HMG 2011 - ChIP-seq Palmieri HMG ) Genesymbol Chrom Start End TSS Position View RRAGC chr1 39325313 39325853 0 IGV

Copyright © 2020 Tigem. Designed by Diego Carrella in collaboration with Rossella De Cegli
Data produced by Ballabio’s and di Bernardo’s lab

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